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Importance: Vascular endothelial growth factor plays a role in proliferative diabetic retinopathy PDR. Intravitreal injection of saline has been shown potentially to lead to improved visual acuity compared with observation alone in eyes with vitreous hemorrhage. Therefore, it is important to determine if intravitreal anti-vascular endothelial growth factor can reduce vitrectomy rates and risks associated with vitrectomy compared with saline for vitreous hemorrhage from PDR that precludes placement or confirmation of complete panretinal photocoagulation. Objective: To evaluate intravitreal ranibizumab compared with intravitreal saline injections on vitrectomy rates for vitreous hemorrhage from PDR.
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